Why protein mutations lead to familial form of Parkinson's disease

For the first time, researchers have shown why protein mutations lead to the familial form of Parkinson's disease. Parkinson's disease is characterized by impairment or deterioration of neurons in an area of the brain known as the substantia nigra. In the familial form of the disorder, a set of mutations in ?syn had been identified but what was unknown was the molecular mechanism by which these mutations caused disease.